Table 7:
Hazard ratio of cardiovascular mortality associated with a double increase in baseline serum-free kynurenine level (mg/L).
| Free kynurenine (mg/L) | |
|---|---|
| Unadjusted HR [95% CI]—P-value | 2.3 [1.7, 3.03]–<0.001 |
| Adjusted HR a [95% CI]—P-value | 1.8 [1.3, 2.5]–0.001 |
| Adjusted HR b [95% CI]—P-value | 1.66 [1.1, 2.5]–0.01 |
| Adjusted HR c [95% CI]—P-value | 1.64 [1.1, 2.4]–0.007 |
a
Model adjusted for age at baseline, sex, high-sensitivity C-reactive protein, serum albumin, urea, diabetes, dyslipidemia, body mass index, smoking status, baseline estimated glomerular filtration rate, urine albumin- or protein-to-creatinine ratio, systolic blood pressure, prescriptions of diuretics, antihypertensive drugs, lipid-lowering drugs, and antidiabetic drugs.
b
1 + serum-free tryptophan.
c
1 + serum-free indoxyl sulfate, indole-3-acetic acid and p-cresyl sulfate.