Table 5.
Statistics of the number of proteins and protein–protein interactions in interactome databases that are mapped to human reference proteome
| Database | Total number of | Number of proteins with available structures | Number of interactions with structures available for both interacting proteins | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Interactions | Proteins | PDB | SWISS-MODEL | ModBase | AFa | PDB | SWISS-MODEL | ModBase | AFa | |
| HuRI | 48 763 | 7889 | 3317 | 3414 | 3729 | 2026 | 7046 | 7014 | 8938 | 2737 |
| BioPlex v3.0 | 53 136 | 8806 | 3888 | 4242 | 4615 | 2819 | 14 036 | 13 945 | 15 162 | 5802 |
| STRING v11.5 | 57 192 | 7327 | 4518 | 4214 | 4095 | 2085 | 38 005 | 24 829 | 21 442 | 9941 |
| HIPPIE v2.3 | 22 280 | 7640 | 4164 | 3971 | 4231 | 1910 | 10 193 | 7795 | 8412 | 1586 |
| APID v2021_03 | 125 722 | 14 854 | 6508 | 6774 | 7236 | 3897 | 39 922 | 32 453 | 36 390 | 8394 |
| PICKLE v3.3 | 211 943 | 15 922 | 6852 | 4349 | 7719 | 4191 | 88 408 | 68 328 | 71 761 | 14 794 |
| BioGRID v4.4.216 | 719 566 | 17 100 | 6914 | 7499 | 8174 | 4587 | 292 081 | 233 361 | 239 226 | 70 455 |
| IID v2021_05 | 542 157 | 17 331 | 7015 | 7636 | 8250 | 4600 | 235 632 | 181 337 | 185 030 | 53 251 |
Additional filtering was applied to STRING and HIPPIE datasets.
aAF, 85% of the residues predicted with ≥70% pLDDT score.