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. Author manuscript; available in PMC: 2024 Jan 5.
Published in final edited form as: J Med Chem. 2023 Aug 21;66(17):11831–11842. doi: 10.1021/acs.jmedchem.3c00406

Figure 4. Interactions of Api-137 with the residues of the 23S rRNA.

Figure 4.

(A) Structure of ribosome-bound Api137 (orange). (B) Close-up view of the interactions of the C-terminal Arg17 and Leu18 residues of Api137 with the GGQ motif of RF1 (magenta) and A76 of the deacylated P-site tRNA (navy). H-bonds are shown with dotted lines. (C, D) π-π stacking interactions (light yellow) of Api residues (orange) with the nucleotides of the 23S rRNA (cyan). Ribosomal protein L22 is shown in light green. Figure rendered from PDB 5O2R.