Table 2.

The sequences and minimum inhibitory concentrations and fold changes for Api-137, Tyr7-modified peptides, and His15-modified peptides.

Peptide	Sequence	Unnatural Amino Acid	MIC (μM)	Fold change
Api-137	gu-ONNRPVYIPRPRPPHPRL-OH	none	0.16–0.35	1
9	gu-ONNRPVyIPRPRPPHPRL-OH	y = p-OMe-phenylalanine	1.5	4
10	gu-ONNRPVyIPRPRPPHPRL-OH	y = p-F-phenylalanine	0.35	1
11	gu-ONNRPVyIPRPRPPHPRL-OH	y = cyclohexylalanine	0.75	2
12	gu-ONNRPVYIPRPRPPhPRL-OH	h = naphthylalanine	10	63
13	gu-ONNRPVYIPRPRPPhPRL-OH	h = cyclohexylalanine	5	32
14	gu-ONNRPVYIPRPRPPWPRL-OH	W = tryptophan	1.2–2.5	8–16