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The minimum inhibitory concentration of Api-137, compound 3, 27 and 29 against the following E. coli strains: BL21, BL21 ΔsbmA, BL21 RF2(R262C) and BL21 RF2(Q280L) to confirm whether the compounds have the same mechanism of action as Api-137.
| Compound | BL21 | BL21 ΔsbmA | BL21 RF2(R262C) | BL21 RF2(Q280L) |
|---|---|---|---|---|
| Api 137 | 1.5 | >25 | >25 | >25 |
| 3 | 3.1 | >25 | >25 | 25 |
| 27 | 1.5 | >25 | >25 | 12.5 |
| 29 | 3.1 | >25 | 6.2 | 3.1 |
