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. 2023 Dec 20;41(1):msad279. doi: 10.1093/molbev/msad279

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© The Author(s) 2023. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 6. — The relationship of phylogenetic diversity decay metrics with age and age-related cancer risk. a) Normalized phylogeny imbalance (α) in HSC phylogenies from healthy individuals increases following an exponential function: α = 0.002×e^0.09×age (R² = 0.89). b) Normalized HSC lineage count (β) increases following an exponential function: β = 0.003×e^0.08×age (R² = 0.87).