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. 2023 Dec 20;41(1):msad279. doi: 10.1093/molbev/msad279

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© The Author(s) 2023. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 8. — Application of the phyloAge model to the phylogenies of MPN patients. a) PhyloAges of individuals with MPN are substantially greater than their true chronological ages. A 1:1 relationship (dashed line) is shown for comparison. b) The HSC phylogeny of a 49-yr-old individual with MPN. Only 3 of 92 HSCs trace their direct origin back to the root, and one subclonal lineage gives rise to a vast majority of HSCs present at age 49, which displayed almost all the primary HSC lineages. c) The logged LTT plot from a 49-yr-old individual with MPN exhibits an initial rapid diversification in HSCs, a period of growth, and then a second period of increase later in life, much like the older healthy person, but much sooner.