Table 2.

WMH-by-Aβ load ANOVAs of hippocampal functional connectivity during the face-name associative memory task (corrected p <0.05, controlling for age and sex).

WMH -by-Aβ ANOVAs	Brain region	Brodmann area (BA)	Peak MNI coordinates (x,y,z)	t *	Size (mm3)
Right hippocampal functional connectivity
Main effect of WMH (WMH(+)<WMH(−))	R SMA	BA6,24	10,−2,54	3.35	616
Main effect of Aβ	None
WMH by Aβ interaction	R PH/HP		26,−32,−10	4.08	744
	R ACC	BA32	16,50,−2	−3.93	632
	L ACC	BA32,24	−8,40,2	−3.62	816
	L ACC	BA 32	−6,40,20	−3.32	528
	R precentral/RO	BA6,44	60,0,20	−3.79	1304
Left hippocampal functional connectivity
Main effect of WMH (WMH(+)<WMH(−))	R Precental/MFG	BA6,9	40,6,38	4.83	3088
Main effect of Aβ	R MFG/IFG	BA46	40,42,6	3.75	816
WMH by Aβ interaction	Tail of L HP/PH		−28,−38,−6	−6.33	1104

^*Degree of freedom = [1, 55]

Abbreviations: MNI-Montreal Neurologic Institute; R-right, L-left; PH-parahippocampus, HP-hippocampus, SMA-supplementary motor area, ACC-anterior cingulate cortex, mPFC-medial prefrontal cortex, IFG-inferior frontal gyrus, MFG-middle frontal gyrus. Brain region PH/PH or HP/PH represents a cluster encompassing both hippocampus and parahippocampus, with PH/PH for more parahippocampal voxels and HP/PH for more hippocampal voxels in the cluster.