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. 2023 Aug 25;26(1):55–67. doi: 10.1093/neuonc/noad155

Figure 5.

Figure 5.

Sirt2i impacts H4K16ac levels to influence phenotypically relevant gene expression in the Atrx-deficient context. (A) Venn diagrams showing shared and unique ChIP-seq peaks for H4K16ac in Atrx + and Atrx− mNPCs, with hypergeometric P value. (B) GSEA correlations for gene sets associated with Sirt2i-mobilized H4K16ac peaks in Atrx + and Atrx− mNPCs. (C) H4K16ac MEME analysis in 1uM AGK2 treated Atrx- mNPCs implicating KLF16, JUN, SP1, and zinc finger family members as key transcriptional cofactors. (D) Heatmap showing broad shifts in the expression levels of MEME-associated KLF16 target genes in Sirt2i-treated Atrx− mNPCs. GSEA associations with Sirt2i-modulated KLF16 target transcripts showing negative (E) and positive (F) correlations with relevant motility and apoptotic networks.