Table 3.

Linear Mixed Model Estimates for MADRS Scores

MADRS scores from post-infusion days 1 to 3
	Coefficient	95% CI	t-value	p-value
Intercept	16.6	11.3 to 21.9	6.15	<0.001
Group	−5.82	−13.3 to 1.64	−1.53	0.13
Time	0.24	−2.04 to 2.52	0.21	0.84
Group×Time	1.70	−1.54 to 4.93	1.03	0.30
Change from pre-infusion baseline MADRS scores on post-infusion days 1 to 3
	Coefficient	95% CI	t-value	p-value
Intercept	−15.0	−20.1 to −9.95	−5.79	<0.001
Group	0.82	−6.25 to 7.89	0.23	0.82
Time	0.58	−1.77 to 2.93	0.49	0.63
Group×Time	1.33	−1.96 to 4.62	0.79	0.43

MADRS, Montgomery–Åsberg Depression Rating Scale. CI, confidence interval. The effect of group on MADRS scores from post-infusion days 1 to 3 was not significant (p=0.13 using absolute scores and p=0.82 using change from baseline scores). Significance was evaluated using likelihood ratio tests and applying the normal approximation to Wald t values from the model output. No adjustments for multiple comparisons were made for the two models presented here.