Extended Data Fig. 7 |. The overall AF2 structure of the 5-HT2A receptor used in this study leans more towards an inactive state.

The AF2, Cryo-EM structure in an active state (PDB ID: unpublished), and the crystal structure in an inactive state (PDB ID: 6A93) are depicted in a cartoon representation and are colored in yellow, cyan, and marine, respectively. The transmembrane helix TM6 from the AF2 structure aligns more closely with that of the crystal structure in its inactive state than with the Cryo-EM structure in its active state.