Skip to main content
[Preprint]. 2024 Mar 13:2023.12.20.572662. Originally published 2023 Dec 21. [Version 2] doi: 10.1101/2023.12.20.572662

Extended Data Figure 9 |. Functional screening of the prioritized library against the 5-HT2B and 5-HT2C receptors.

Extended Data Figure 9 |

Libraries from cryoEM (left) and AF2 (right) docking were screened at 3 μM in a calcium mobilization functional screen against the 5-HT2B (panel a) and 5-HT2C (panel b) receptors in agonist mode (top) or antagonist mode (bottom). Dashed lines indicate 10% maximal 5-HT response or 20% maximal clozapine response for agonists and antagonists, respectively. Data represent the mean ± s.e.m. from 3-4 biological replicates.