Extended Data Table 2.

Binding affinities for compounds that displace ≥ 90% [³H]-LSD at the 5-HT2A receptor.

Compound	log(Ki)	Ki	Ki (nM)	Model
Z7704262288	−7.82 ± 0.073	1.52E-08	15	AF2
Z7619689892	−7.78 ± 0.077	1.68E-08	17	AF2
Z2945615615	−7.62 ± 0.104	2.40E-08	24	AF2
Z5247694451	−7.15 ± 0.073	7.10E-08	71	cryoEM
Z7619689909	−7.14 ± 0.078	7.22E-08	72	AF2
Z3881312504	−7.02 ± 0.062	9.59E-08	96	AF2
Z3517963976	−6.95 ± 0.085	1.13E-07	113	cryoEM
Z3865153101	−6.94 ± 0.099	1.14E-07	114	cryoEM
Z2449215308	−6.79 ± 0.100	1.62E-07	162	AF2
Z5247693829	−6.77 ± 0.078	1.71E-07	171	cryoEM
Z1441676226	−6.77 ± 0.087	1.71E-07	171	cryoEM
WXVL_BT0793LQ2118	−6.68 ± 0.087	2.07E-07	207	AF2
Z1348472291	−6.65 ± 0.083	2.22E-07	222	cryoEM
Z3808146201	−6.51 ± 0.096	3.08E-07	308	cryoEM
Z2393190959	−6.51 ± 0.085	3.12E-07	312	AF2
Z5247693129	−6.49 ± 0.094	3.26E-07	326	cryoEM
Z7619689903	−6.46 ± 0.086	3.44E-07	344	AF2