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[Preprint]. 2023 Dec 23:2023.12.22.572877. [Version 1] doi: 10.1101/2023.12.22.572877

Figure 3. DRF treatment fails to prevent mechanical hypersensitivity in Nrf2KO mice.

Figure 3.

Wild-type and Nrf2KO animals were treated with DRF at 100 mg/kg based on the paradigm outlined in Fig 1A. MGO (20 ng) was injected into the paw on day 3 since the start of oral DRF treatment in wild-type (n=8, 4 males and 4 females) and Nrf2KO (n=8, 4 males and 4 females) littermates. Nrf2KO animals developed mechanical hypersensitivity compared to the wild-type animals suggesting that DRF treatment was unable to prevent MGO-induced hypersensitivity in Nrf2KO animals. A repeated measures two-way ANOVA was used followed by Sidak’s post hoc test. *p<0.05, **p<0.01, ***p<0.001.