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[Preprint]. 2023 Dec 23:2023.12.22.572877. [Version 1] doi: 10.1101/2023.12.22.572877

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Figure 6. — (A-C) Example images of human DRG neurons immunolabeled with β3 tubulin (green) to visualize neuronal cell body and nerites. Neurons were treated with vehicle, MGO (1μM), or MGO (1μM) plus MMF (10, 20, 50 μM) for 24 hours prior to fixation and immunostaining. (D) Sholl analysis was performed to quantify neurite outgrowth and complexity. (E) Area under the curve of Sholl analysis shows that MMF treatment prevents MGO-induced neurite outgrowth, particularly at 20 μM and 50 μM concentrations. Vehicle-only (n=24), MGO (n=25), MGO+10μM MMF (n=27), MGO+20μM MMF (n=27), MGO+50μM MMF (n=23). A one-way ANOVA was used to calculate statistical significance. *p<0.05, ***p<0.001, ****p<0.0001.