Table 1.
Summary of case reports/series of oral tyrosine kinase inhibitors causing macula edema (Literature review: PubMed, Embase) [2, 3]
| Publication | Tyrosine kinase inhibitor agent | Indication | Ocular toxicity |
|---|---|---|---|
| Masood et al. [4] (2005) | Imatinib (Gleevec) | Chronic lymphocytic leukemia (CLL) | Cystoid macula edema |
| Georgalas et al. [5] (2007) | Imatinib (Gleevec) | Chronic myeloid leukemia (CML) | Cystoid macula edema |
| McClelland et al. [3] (2010) | Imatinib (Gleevec) | Chronic myeloid leukemia (CML) | Periorbital edema |
| Kusumi et al. [6] (2004) | Imatinib (Gleevec) | Chronic lymphocytic leukemia (CLL) | Cystoid macula edema |
| Georgalas, [7] (2007) | Imatinib (Gleevec) | Chronic myeloid leukemia (CML) | Cystoid macula edema |
| Roth et al. [8] (2009) | Imatinib (Gleevec) | Chronic myeloid leukemia (CML) | Macula ischemia |
| Dogan et al. [9] (2009) | Imatinib (Gleevec) | Solid tumor (gastrointestinal stromal) | Cystoid macula edema, conjunctival hemorrhage, optic neuritis |
| Bajel et al. [10] (2008) | Imatinib (Gleevec) | Chronic myeloid leukemia (CML) | Cystoid macula edema |
| Saenz-de-Viteri et al. [11] (2019) | Ibrutinib (Imbruvica) | Chronic lymphocytic leukemia (CLL) | Cystoid macula edema |
| Mirgh et al. [12] (2020) | Ibrutinib (Imbruvica) | Chronic lymphocytic leukemia (CLL) | Cystoid macula edema |