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. 2023 Aug 21;29(1):e118–e130. doi: 10.1093/oncolo/oyad238

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© The Author(s) 2023. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Representative examples of the microscopic alterations found in colic mucosa of patients treated with immune checkpoint inhibitors. (A) Crypt atrophy. (B) Apoptotic bodies within a gland. (C) Mild crypts’ distortion. (D) Lamina propria expansion and mucin depletion. (E) Collagenous band. (F). CD3 immunostaining showing moderate intraepithelial lympho-monocitic infiltrate. (G) Lympho-monocitic and plasmacellular infiltrate within the lamina propria. (H) Granulocytic infiltrate within the lamina propria associated with cryptitis. (I) Cryptic abscess. (J) Subepithelial macrophages. (K) Ischemic-like colitis features and superficial erosion. (L) Paneth metaplasia.