Table 3.
Microscopic features of available biopsies of patients experiencing immune-mediated diarrhea and colitis.
| Variable | N (%) |
|---|---|
| Number of cases | 25 (100.0) |
| Crypt atrophy/loss | |
| Present | 12 (48.0) |
| Absent | 13 (52.0) |
| Crypt distortion | |
| Present | 15 (60.0) |
| Absent | 10 (40.0) |
| Mucin depletion | |
| Present | 20 (80.0) |
| Absent | 5 (20.0) |
| Apoptotic bodies | |
| Present | 19 (76.0) |
| Absent | 6 (24.0) |
| Lamina propria expansion | |
| Present | 21 (84.0) |
| Absent | 4 (16.0) |
| Collagenous band | |
| Absent | 16 (64.0) |
| Focal | 5 (20.0) |
| Extensive | 4 (16.0) |
| Intraepithelial lymphocytes | |
| Absent | 1 (4.0) |
| 0-2/100 enterocytes | 11 (44.0) |
| 3-20/100 enterocytes | 13 (52.0) |
| >20/100 enterocytes | 0 (0.0) |
| Lymphomonocytic infiltrate | |
| Absent | 0 (0.0) |
| Mild | 8 (32.0) |
| Moderate | 17 (68.0) |
| Heavy | 0 (0.0) |
| Granulocyte infiltrate | |
| Absent | 13 (52.0) |
| Mild | 11 (44.0) |
| Moderate | 1 (4.0) |
| Heavy | 0 (0.0) |
| Cryptitis | |
| Absent | 20 (80.0) |
| Focally present | 3 (12.0) |
| Focally present | 2 (8.0) |
| Crypt abscess | |
| Present | 2 (8.0) |
| Absent | 23 (82.0) |
| Subepithelial macrophages | |
| Present | 6 (24.0) |
| Absent | 19 (76.0) |
| Superficial erosion/ulceration | |
| Present | 5 (20.0) |
| Absent | 20 (80.0) |
| Ischemic colitis like | |
| Present | 6 (24.0) |
| Absent | 19 (76.0) |
| Paneth metaplasia | |
| Present | 7 (28.0) |
| Absent | 18 (72.0) |
| Global score | |
| 1 | 9 (36.0) |
| 2 | 9 (36.0) |
| 3 | 7 (28.0) |