Figure 1.
Patient flow diagram. (A) Definition of the assessable population and patient placement in the ETS-unachieved (ETS <20% at 6 weeks) and ETS-achieved groups (ETS ≥20% at 8 weeks) based on the treatment arm. (B) Definition of the assessable population and patient placement in the DpR-low (DpR <40% within 12 weeks) and DpR-high groups (DpR ≥40% within 12 weeks) based on the treatment arm. Abbreviations: ETS: early tumor shrinkage; GC: gemcitabine plus cisplatin; GS: gemcitabine plus S-1; PFS: progression-free survival; DpR: depth of response.