. 2023 Nov 30;29(1):84–88. doi: 10.1093/oncolo/oyad310

Table 1.

Immunohistochemical and molecular biomarkers of lung and thyroid carcinoma.

	NSCLC		Non-anaplastic thyroid carcinoma (%)
	Adenocarcinoma (%)	Squamous cell carcinoma (%)	Non-anaplastic thyroid carcinoma (%)
IHC biomarkers
TTF-1	80-85	1	90%-100%
p63	33	94	70^a
p40	16	94	≈0
CK7	95	≈0	97
CK5/6	2	90	≈0
Napsin-A	74	1	9-30^a
Molecular biomarkers
NTRK rearrangement	<1	≈0	2-6
TERT promoter mutation	3	<2	11^b

^aPapillary thyroid carcinoma, virtually absent in follicular and medullary carcinoma.

^bPapillary thyroid carcinoma; 30%-50% in poorly differentiated histology.

Abbreviations: CK: cytokeratin; IHC: immunohistochemistry; NSCLC: non-small cell lung cancer; NTRK: Neurotrophic Tyrosine Kinase Receptor; TERT: Telomerase Reverse Transcriptase; TTF-1: Transcriptional Thyroid Factor 1.