Table 2.
Respiratory mechanics and Electrical Impedance Tomography based measurements at the optimal Positive End-Expiratory Pressure (PEEP) levels computed for each tested PEEP titration strategy
| CoV | Crossing Point | Express | Positive PLe | ANOVA p value | |
|---|---|---|---|---|---|
| PEEPtot, cmH2O | 20 [19–20]* | 11 [10–12]† | 18 [16–19]* | 7 [10–14]† | < .001 |
| Pplat, cmH2O | 31 [27–34]* | 19 [17–20]† | 27 [27–28]* | 18 [14–21]† | < .001 |
| PLe, cmH2O | 7 [3–10]* | 2 [0–3]† | 6 [3–7]* | 2 [1– 2]† | < .001 |
| PLi, cmH2O | 13 [10–22]* | 7 [3–10]† | 12 [10–15]* | 7 [5–10]† | < .001 |
| PplatL, cmH2O | 23 [16–27]* | 14 [10–15]† | 19 [16–22]* | 11 [8–15]† | < .001 |
| ΔPRS, cmH2O | 11 [9–13]* | 8 [7–10]† | 9 [8–10]* | 7 [7–10]† | < .001 |
| CRS, mL. cmH2O−1 | 41 [28–50]* | 54 [43–67]† | 45 [42–56]* | 59 [41–71]† | < .001 |
| CL, mL. cmH2O−1 | 53 [34–67]* | 75 [61–133]† | 63 [53–88]* | 77 [58–141]† | < .001 |
| OD, % | 24 [15–29]* | 9 [6–13]† | 21 [18–26]* | 5 [0–14]† | < .001 |
| LC, % | 0 [0–1]* | 9 [4–10]† | 1 [0–2]* | 9 [2–14]† | < .001 |
| CoV, % | 53 [51–56]* | 57 [53–60]† | 54 [51–57]* | 56 [55–59]† | < .001 |
| VREC from PEEP 5 cmH2O, mL | 511 [216–785]* | 232 [140–401]† | 517 [239–749]* | 124 [0–155]†* | < .001 |
| VREC/PBW from PEEP 5 cmH2O, mL.kg−1 | 7.4 [3.5–10.9]* | 3.3 [2.3–4.9]† | 7.5 [3.7–10.8]* | 1.5 [0.0–2.6]†* | < .001 |
CL Lung compliance, CoV Center of Ventilation, CRS respiratory system compliance, LC Lung Collapse, OD OverDistension, PEEPtot total Positive End-Expiratory Pressure, PLe expiratory transpulmonary pressure, PLi inspiratory transpulmonary pressure, Pplat plateau pressure, PplatL plateau pressure applied to the lung, ΔPRS respiratory system driving pressure. *Significantly different from Crossing Point method (p < 0.05), †Significantly different from CoV method (p < 0.05)