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. 2023 Sep 20;34(1):11–12. doi: 10.1038/s41422-023-00878-0

Fig. 1. LICOB establishment and multi-omics analyses of liver cancer organoids.

Fig. 1

PLC tissues were collected from patients to generate LICOB. In total, 65 organoids were established from 57 patients, including HCC (n = 44), ICC (n = 12), CHC (n = 4) and HB organoids (n = 5). Multi-omics analyses of these organoids were performed by using reduced representation bisulfite sequencing (RRBS), whole-exome sequencing (WES), RNA-seq, and label-free proteomics. The sensitivity of the organoids to 76 approved or investigational drugs was tested.