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. 2024 Jan 5;7:31. doi: 10.1038/s42003-023-05692-3

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© The Author(s) 2024, corrected publication 2024

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Fig. 7 — a Dynamic changes in transcriptomes of dnmt1 and pole1 single and double mutants, as indicated by principal component analysis. b Venn diagram indicating the overlap of differentially expressed genes for down-regulated and up-regulated genes in fish of the indicated genotypes. c Four clusters of co-regulated genes are identified in dnmt1 mutant fish; each column represents a biological replicate. d Co-regulation of groups of genes in (c) identifies 2 gene clusters with restored wild-type levels in dnmt1/pole1 double mutants; box plots (mean; box, upper/lower quartile; whiskers, minimal/maximal values).