Fig. 1.

Bioinformatics analysis of hepatic pathways and genes in liver fibrosis. (a) Volcano plot of microarray data, generated by clustering based on probes enriched or depleted (fold change greater than 2; adjusted-P < 0.05) in CCl4-treated mice compared to vehicle mice; (b) Heatmap displaying relative expression of genes related to autophagy, ferroptosis, mitophagy and oxidative phosphorylation in the liver (n = 4–6); (c, d) GSEA analysis and GSVA score of distinct biological processes in healthy and disease groups. (n = 5); and (e) GSVA score partial correlation.