TABLE 2.

Risk-of-bias analysis of studies included in the systematic review examining the effects of exercise interventions on the gut microbiome in animal models.

Study	Selection of participants free from bias	Study with >80% follow up a	Standard/valid/reliable data collection procedures	QCC rating b , c
Castro et al. (2021)	Yes	Yes	Yes	∅
Chen et al. (2021)	Yes	Unclear	Yes	-
De Almeida et al. (2016)	Yes	Yes	Yes	+
Giacco et al. (2020)	Yes	No	Yes	∅
Houghton et al. (2018)	Yes	Unclear	Yes	∅
Janabi et al. (2017)	Yes	Yes	Yes	∅
Janabis et al. (2016)	Yes	Yes	Yes	∅
Lamoureux et al. (2017)	Yes	Unclear	Yes	∅
Meng et al. (2020)	Yes	Yes	Yes	∅
Mika et al. (2015)	Yes	No	Yes	∅
Ribeiro et al. (2019)	Yes	No	Yes	∅
Walshe et al. (2021)	No d	Yes	Yes	∅
Yang et al. (2021)	Yes	Unclear	Yes	∅

^a Follow-up here takes into account participant attrition or participants included in analysis.

^b QCC, quality criteria checklist.

^c QCC, rating: +, report has clearly addressed issues of inclusion/exclusion, bias, generalizability, and data collection and analysis; -, report has not addressed these issues adequately; and ∅, report is neither exceptionally strong nor exceptionally weak.

^d Client-owned, not experimental animals.