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. 2024 Jan 5;14:641. doi: 10.1038/s41598-024-51224-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Alterations in microbial, plasmatic, and testicular metabolic profiles caused by dapagliflozin administration. (A–C) Principal component analysis (PCA) plots of metabolomic profiles from cecum (A), plasma (B), and testis (C). (D–F) The Log2-fold change (Log₂FC) of the 17, 12 and 12 metabolites that were rescued by dapagliflozin in cecum (D), plasma (E) and testis samples (F). (G–I) Representative 10, 10 and 6 KEGG pathways of the dapagliflozin rescued microbial (G), plasmatic (H) and testicular metabolites (I). Rich factor was shown as -Log2 and the enriched KEGG pathways involved adenosine, cAMP and deoxyinosine were presented in red. (J) The relationship of adenosine, cAMP and deoxyinosine in the purine metabolism pathway.