Fig. 5.

Panel A. IPA analysis focusing on the onset and development of the inflammatory state (TNFα vs. CTR) identified TNFα as a potential upstream regulator; the wheel of modulated proteins is consistent with TNFα stimulation. Color legend: red represents the upregulated genes, green the downregulated. The intensity of the color is related to the intensity of up- or down-regulation. The orange line leads to activation and a blue line leads to inactivation. The yellow line indicates findings that are not consistent with the proteomics results obtained. Panel B. STRING analysis of the modulated gene products determined by IPA, shown as a protein–protein interaction network obtained; the color/s of each node (gene product) reflect/s the functional enrichment analysis performed whose code is shown below the network.