Fig. 6.

Panel A. IL4 was enriched as a potential upstream regulator determined in the TNFα vs. CTR condition by means of IPA analysis (LFQ); the dataset allows a hypothesis of IL4 inhibition to be generated. PTGS2 is circled in red due to the high interest as to the involvement of this protein, whose Log2 fold-change and p-value values are shown in panel B, alongside the Log2 fold-change and p-value values of ABCC4 closely related to PTGS2. Color legend: red represents the upregulated genes, green the downregulated. The intensity of the color is related to the intensity of up- or down-regulation. The orange line leads to activation and a blue line leads to inactivation. The yellow line indicates findings that are not consistent with the proteomics results obtained.