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. 2023 Nov 20;64(12):100479. doi: 10.1016/j.jlr.2023.100479

Fig. 9.

Fig. 9

MCF7 and MDA-231 cells were treated or not for 48 h with OCDO (1 μM), 27HC (1 μM) or 27OH-OCDO (1 μM) alone or in combination. Cells were harvested by trypsinization and counted on a counting chamber Mallassez as described in Materials and Methods. Cell number are expressed as the percentage relative to control (vehicle) (A–C). Kaplan–Meier representation of patient recurrence free survival taking into account the expression (median cut-off) of the HSD11B2 (D), CYP27A1 (E) or HSD11B2 and CYP27A1 (F) genes using the Kmplot database on 50 individual datasets (4,934 samples) on all BC. Kaplan–Meier representation of ER-negative breast cancer patient recurrence free survival taking into account the expression (median cut-off) of the HSD11B2 (G), CYP27A1 (H) or HSD11B2 and CYP27A1 (I) genes using the Kmplot database on 50 individual datasets (1161 samples). Survival curves are based on Kaplan–Meier estimates and log-rank P values were calculated for differences in survival. Cox regression analysis was used to calculate hazard ratio (HR).