Table 3.

Analysis of maximal oxidative capacity and oxygen affinity in isolated mitochondria from mice receiving chronic treatment with vehicle, low-dose (400 ng/kg/min), or high-dose (1,000 ng/kg/min) angiotensin II for 4 weeks.

Treatment	n	State 4 respiration (pmol O2/s/mg protein)	Complex I dependent State 3 respiration (pmol O2/s/mg protein)	Complex I+II dependent State 3 respiration (pmol O2/s/mg protein)	P50 (kPa)
Vehicle	7–8	0.78 ± 0.03	5.8 ± 0.3	13.5 ± 0.3	0.083 ± 0.004
Low-dose angiotensin II	6–8	1.06 ± 0.06*	8.5 ± 0.7*	16.1 ± 1.2	0.075 ± 0.002
High-dose angiotensin II	7–8	0.61 ± 0.03*#	3.8 ± 0.3*#	9.0 ± 0.6*#	0.086 ± 0.005

P50: mitochondrial oxygen affinity.

All values are means ± SEM.

^*denotes P < 0.05 compared to vehicle-treated group, and

^#denotes P < 0.05 compared to low-dose treatment.