Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 5;223(2):e202312096. doi: 10.1083/jcb.202312096

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2024 Sun et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 1. — In the intestinal epithelium of C. elegans, conventional secretion cargoes are trafficked along the ER-ERGIC-Golgi pathway, while leaderless cargoes, such as PGP-1, are secreted through unconventional secretion pathways. SMGL-1, which is resident on the ERGIC, activates RAB-8, facilitating its recruitment to the endosome. Subsequently, RAB-8 interacts with the Q-SNARE VIT-1. Additionally, PGP-1 is secreted from the ERGIC and the vesicles containing PGP-1 may form secretory autophagosomes. RAB-11 recruits RABI-8 to attenuate RAB-8 activity by reducing SMGL-1 self-oligomerization. Ultimately, RAB-11–positive endosomes fuse with the plasma membrane, facilitating the transport of PGP-1 to the apical membrane.