Table 3.
Serotypes of the isolates responsible for non-invasive pneumococcal pneumonia in adult patients (≥18 years) in Portugal, 2012–2018.
| Serotypea | No of isolates (%) | CA 16–18b | CA 12–18b | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Current study period | |||||||||
| 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | |||
| PCV13 | |||||||||
| 3 | 48 (13.0) | 54 (16.9) | 41 (13.4) | 53 (12.5) | 52 (13.4) | 56 (14.4) | 60 (16.2) | 0.275 | 0.610 |
| 4 | 1 (0.3) | 1 (0.3) | 2 (0.7) | 3 (0.7) | 0 (0.0) | 0 (0.0) | 1 (0.3) | 0.211 | 0.400 |
| 6A | 5 (1.4) | 7 (2.2) | 6 (2.0) | 9 (2.1) | 5 (1.3) | 3 (0.8) | 1 (0.3) | 0.112 | 0.041 |
| 6B | 7 (1.9) | 4 (1.3) | 4 (1.3) | 6 (1.4) | 3 (0.8) | 3 (0.8) | 3 (0.8) | 0.954 | 0.102 |
| 7F | 5 (1.4) | 4 (1.3) | 4 (1.3) | 5 (1.2) | 0 (0.0) | 1 (0.3) | 2 (0.5) | 0.146 | 0.021 |
| 9V | 0 (0.0) | 5 (1.6) | 0 (0.0) | 0 (0.0) | 1 (0.3) | 1 (0.3) | 1 (0.3) | 0.973 | 0.400 |
| 14 | 12 (3.3) | 6 (1.9) | 6 (2.0) | 10 (2.4) | 13 (3.3) | 8 (2.1) | 7 (1.9) | 0.191 | 0.534 |
| 18C | 4 (1.1) | 1 (0.3) | 1 (0.3) | 1 (0.2) | 3 (0.8) | 4 (1.0) | 1 (0.3) | 0.413 | 0.759 |
| 19A | 17 (4.6) | 9 (2.8) | 18 (5.9) | 14 (3.3) | 10 (2.6) | 11 (2.8) | 11 (3.0) | 0.741 | 0.104 |
| 19F | 22 (6.0) | 22 (6.9) | 15 (4.9) | 26 (6.1) | 26 (6.7) | 16 (4.1) | 28 (7.5) | 0.639 | 0.903 |
| 23F | 4 (1.1) | 2 (0.6) | 4 (1.3) | 2 (0.5) | 4 (1.0) | 2 (0.5) | 2 (0.5) | 0.413 | 0.378 |
| addPCV15 | |||||||||
| 22F | 14 (3.8) | 8 (2.5) | 6 (2.0) | 21 (5.0) | 15 (3.9) | 11 (2.8) | 13 (3.5) | 0.781 | 0.827 |
| 33F | 6 (1.6) | 1 (0.3) | 7 (2.3) | 3 (0.7) | 5 (1.3) | 4 (1.0) | 3 (0.8) | 0.518 | 0.474 |
| addPCV20 | |||||||||
| 11A | 29 (7.9) | 29 (9.1) | 22 (7.2) | 40 (9.5) | 34 (8.7) | 28 (7.2) | 40 (10.8) | 0.332 | 0.421 |
| 8 | 7 (1.9) | 10 (3.1) | 6 (2.0) | 16 (3.8) | 11 (2.8) | 16 (4.1) | 16 (4.3) | 0.278 | 0.039 |
| 15B/C | 6 (1.6) | 11 (3.4) | 7 (2.3) | 10 (2.4) | 7 (1.8) | 16 (4.1) | 13 (3.5) | 0.172 | 0.134 |
| 10A | 11 (3.0) | 6 (1.9) | 5 (1.6) | 10 (2.4) | 13 (3.3) | 13 (3.3) | 8 (2.2) | 0.339 | 0.661 |
| addPPV23 | |||||||||
| 9N | 11 (3.0) | 13 (4.1) | 16 (5.2) | 12 (2.8) | 20 (5.1) | 23 (5.9) | 17 (4.6) | 0.737 | 0.122 |
| 20 | 5 (1.4) | 5 (1.6) | 6 (2.0) | 8 (1.9) | 9 (2.3) | 4 (1.0) | 6 (1.6) | 0.442 | 0.994 |
| 17F | 8 (2.2) | 4 (1.3) | 8 (2.6) | 4 (0.9) | 4 (1.0) | 6 (1.5) | 7 (1.9) | 0.314 | 0.595 |
| NVT | |||||||||
| 23B | 15 (4.1) | 8 (2.5) | 15 (4.9) | 18 (4.3) | 16 (4.1) | 20 (5.1) | 26 (7.0) | 0.078 | 0.025 |
| 23A | 24 (6.5) | 12 (3.8) | 14 (4.6) | 17 (4.0) | 27 (6.9) | 19 (4.9) | 16 (4.3) | 0.107 | 0.692 |
| 29/35B | 12 (3.3) | 6 (1.9) | 6 (2.0) | 10 (2.4) | 9 (2.3) | 22 (5.7) | 12 (3.2) | 0.483 | 0.104 |
| 6C | 19 (5.2) | 16 (5.0) | 7 (2.3) | 22 (5.2) | 11 (2.8) | 13 (3.3) | 15 (4.0) | 0.356 | 0.238 |
| 15A | 10 (2.7) | 9 (2.8) | 8 (2.6) | 16 (3.8) | 15 (3.9) | 15 (3.9) | 8 (2.2) | 0.194 | 0.749 |
| 35F | 5 (1.4) | 3 (0.9) | 6 (2.0) | 14 (3.3) | 18 (4.6) | 9 (2.3) | 4 (1.1) | 0.002 | 0.301 |
| 31 | 15 (4.1) | 7 (2.2) | 14 (4.6) | 12 (2.8) | 6 (1.5) | 14 (3.6) | 9 (2.4) | 0.424 | 0.269 |
| 16F | 7 (1.9) | 10 (3.1) | 3 (1.0) | 20 (4.7) | 12 (3.1) | 12 (3.1) | 1 (0.3) | 0.008 | 0.491 |
| NT | 9 (2.4) | 8 (2.5) | 10 (3.3) | 3 (0.7) | 8 (2.1) | 7 (1.8) | 9 (2.4) | 0.727 | 0.538 |
| 21 | 3 (0.8) | 6 (1.9) | 7 (2.3) | 8 (1.9) | 11 (2.8) | 5 (1.3) | 4 (1.1) | 0.064 | 0.939 |
| 34 | 3 (0.8) | 8 (2.5) | 5 (1.6) | 8 (1.9) | 7 (1.8) | 4 (1.0) | 4 (1.1) | 0.377 | 0.596 |
| 37 | 1 (0.3) | 4 (1.3) | 1 (0.3) | 3 (0.7) | 4 (1.0) | 6 (1.5) | 2 (0.5) | 0.518 | 0.373 |
| 24F | 4 (1.1) | 2 (0.6) | 6 (2.0) | 10 (2.4) | 0 (0.0) | 5 (1.3) | 5 (1.3) | 0.044 | 0.993 |
| 25A/38 | 7 (1.9) | 2 (0.6) | 0 (0.0) | 0 (0.0) | 1 (0.3) | 1 (0.3) | 3 (0.8) | 0.252 | 0.118 |
| 13 | 2 (0.5) | 3 (0.9) | 1 (0.3) | 1 (0.2) | 2 (0.5) | 1 (0.3) | 2 (0.5) | 0.966 | 0.552 |
| 7C | 2 (0.5) | 2 (0.6) | 6 (2.0) | 1 (0.2) | 2 (0.5) | 0 (0.0) | 2 (0.5) | 0.969 | 0.223 |
| 6D | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 3 (0.8) | 0 (0.0) | 0.973 | 0.096 |
| 35A | 2 (0.5) | 3 (0.9) | 4 (1.3) | 2 (0.5) | 1 (0.3) | 0 (0.0) | 2 (0.5) | 0.457 | 0.167 |
| Other | 6 (1.6) | 8 (2.5) | 8 (2.6) | 5 (1.2) | 4 (1.0) | 7 (1.8) | 7 (1.9) | - | |
aOnly serotypes detected in ≥3 isolates in at least 1 year are shown. The remaining serotypes are included in “Other” and include serotypes 18A, 1, 12B, 10B, 47F, 11F, 17A, 10F, 12F, 36, 11B, 7B, 11D, 35C, 18F, 42, 11C, 28A and 19B. PCV13, serotypes included in PCV13; addPCV15, the additional serotypes included in PCV15 which are not present in PCV13; addPCV20, the additional serotypes included in PCV20 which are not present in PCV15; addPPV23, the serotypes exclusively found in PPV23; NVT, non-vaccine serotypes. bCA, Cochran Armitage test for trend for each of the indicated periods: 2016–2018 and 2012–2018. Values < 0.05 are indicated in bold.