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. 2023 Dec 22;14:1298524. doi: 10.3389/fimmu.2023.1298524
CRC colorectal cancer
ICIs immune checkpoint inhibitors
dMMR deficient mismatch repair
MSI-H high microsatellite instability
pMMR proficient mismatch repair
MSS microsatellite stability
TME tumor microenvironment
MLH1 mutL homolog 1
MSH2 mutS homolog 2
MSH6 mutS homolog 6
PMS2 postmeiotic segregation increased 2
mCRC metastatic CRC
CTLA-4 cytotoxic T lymphocyte-associated antigen-4
TAM tumor-associated macrophages
DC dendritic cells
NK natural killer
TILs tumor-infiltrating lymphocytes
CTLs cytotoxic T cells
Tregs regulatory T cells
HLA-G human leucocyte antigen-G
SPP1 secreted phosphoprotein 1
CAFs cancer-associated fibroblasts
MSCs mesenchymal stem cells
ILCs innate lymphoid cells
MHC-I major histocompatibility complex class I
ORR objective response rate
DCR disease control rate
OS overall survival
VEGF vascular endothelial growth factor
TKIs tyrosine kinase inhibitors
RCT randomized controlled trials
PFS progression-free survival
CAR-T chimeric antigen receptor T