CRC | colorectal cancer |
ICIs | immune checkpoint inhibitors |
dMMR | deficient mismatch repair |
MSI-H | high microsatellite instability |
pMMR | proficient mismatch repair |
MSS | microsatellite stability |
TME | tumor microenvironment |
MLH1 | mutL homolog 1 |
MSH2 | mutS homolog 2 |
MSH6 | mutS homolog 6 |
PMS2 | postmeiotic segregation increased 2 |
mCRC | metastatic CRC |
CTLA-4 | cytotoxic T lymphocyte-associated antigen-4 |
TAM | tumor-associated macrophages |
DC | dendritic cells |
NK | natural killer |
TILs | tumor-infiltrating lymphocytes |
CTLs | cytotoxic T cells |
Tregs | regulatory T cells |
HLA-G | human leucocyte antigen-G |
SPP1 | secreted phosphoprotein 1 |
CAFs | cancer-associated fibroblasts |
MSCs | mesenchymal stem cells |
ILCs | innate lymphoid cells |
MHC-I | major histocompatibility complex class I |
ORR | objective response rate |
DCR | disease control rate |
OS | overall survival |
VEGF | vascular endothelial growth factor |
TKIs | tyrosine kinase inhibitors |
RCT | randomized controlled trials |
PFS | progression-free survival |
CAR-T | chimeric antigen receptor T |