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. 2023 Aug 1;57(1):e13529. doi: 10.1111/cpr.13529

FIGURE 5.

FIGURE 5

The exploration of neutrophil migration factors and the relationship between STING and NLRP3/IL‐1β. (A–D) The number of neutrophils extracted from Wild‐type (A), STING−/−(B), IL‐1β−/−(C), NLRP3 −/−(D) mice migrated from the transwell inner chamber into outer chamber, stimulated by Aβ1–42, mtDNA and mixture (Aβ1–42/mtDNA, A+M) for 24 h. n = 3 per group. **0.001 < p < 0.01 versus NS; ***0.0001 < p < 0.001 versus NS; t test; data are means ± SEM. (E–F) ELISA results of IL‐1β expression (E) and immunoblot results of NLRP3 expression (F) of STING−/− neutrophils, stimulated by Aβ1–42, mtDNA for 24 h. (G‐H) Immunoblot results of STING expression in IL‐1β−/−(G) and NLRP3 −/−(H) neutrophils stimulated by Aβ1–42, mtDNA for 24 h. **0.001 < p < 0.01 versus NS; t test; data are means ± SEM.