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. 2023 Dec 16;165(2):bqad191. doi: 10.1210/endocr/bqad191

Figure 4.

Figure 4.

Assays of serum levels of pituitary hormones following a HFD for 10 to 15 weeks. Values were combined as there were no significant changes with time on the diet. The data show elevation only in TSH in males (A) following a HFD. PRL is reduced only in females after a HFD for 15 weeks (B). The overall PRL levels in males (C) are significantly lower than those in females and they are plotted in a separate graph. The sex differences are significant (Tukey's ad hoc tests; adjusted P < .0001). There are no changes in ACTH (D), LH (E), or FSH (F) in either sex with a HFD. Average serum levels of GH did not show a significant change, although variance in GH levels was increased in males (G, test of variance in GH levels of HFD males vs control diet males, F = 35.278, P = 4.975 × 10–05). Furthermore, in females, a rank/plot analysis of individual values showed lower pulses of GH in females on a HFD (H). Except for PRL, analysis of the 4 groups was 2-way ANOVA followed by Tukey's ad hoc tests of significant differences at adjusted P < .05. Analysis of serum PRL showed significance with Student's t and Mann–Whitney tests (P < .02).