Comparison 28. Withdrawals two years: etanercept + disease‐modifying anti‐rheumatic drug (DMARD) vs. DMARD.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Total	2	610	Risk Ratio (M‐H, Random, 95% CI)	0.47 [0.28, 0.80]
1.1 Etanercept 25 mg SC twice weekly	2	610	Risk Ratio (M‐H, Random, 95% CI)	0.47 [0.28, 0.80]
2 Lack of efficacy	2	610	Risk Ratio (M‐H, Random, 95% CI)	0.19 [0.07, 0.48]
2.1 Etanercept 25 mg SC twice weekly	2	610	Risk Ratio (M‐H, Random, 95% CI)	0.19 [0.07, 0.48]
3 Adverse event	2	610	Risk Ratio (M‐H, Fixed, 95% CI)	0.82 [0.57, 1.19]
3.1 Etanercept 25 mg SC twice weekly	2	610	Risk Ratio (M‐H, Fixed, 95% CI)	0.82 [0.57, 1.19]
4 Death	1	459	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.06, 15.68]
4.1 Etanercept 25 mg SC twice weekly	1	459	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.06, 15.68]