Comparison 29. Withdrawals three years: etanercept + disease‐modifying anti‐rheumatic drug (DMARD) vs. DMARD.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Total	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 Etanercept 25 mg SC twice weekly	1	459	Risk Ratio (M‐H, Fixed, 95% CI)	0.70 [0.59, 0.84]
2 Lack of efficacy	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 Etanercept 25 mg SC twice weekly	1	459	Risk Ratio (M‐H, Fixed, 95% CI)	0.30 [0.16, 0.56]
3 Adverse event	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 Etanercept 25 mg SC twice weekly	1	459	Risk Ratio (M‐H, Fixed, 95% CI)	0.66 [0.45, 0.98]
4 Death	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 Etanercept 25 mg SC twice weekly	1	459	Risk Ratio (M‐H, Fixed, 95% CI)	1.97 [0.18, 21.62]