Comparison 31. Withdrawals 12 months: etanercept vs. disease‐modifying anti‐rheumatic drug (DMARD).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Total	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 Etanercept 10 mg SC twice weekly	1	425	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.67, 1.42]
1.2 Etanercept 25 mg SC twice weekly	2	875	Risk Ratio (M‐H, Fixed, 95% CI)	0.76 [0.59, 0.97]
2 Lack of efficacy	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 Etanercept 10 mg SC twice weekly	1	425	Risk Ratio (M‐H, Fixed, 95% CI)	1.96 [0.85, 4.52]
2.2 Etanercept 25 mg SC twice weekly	2	875	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.55, 1.54]
3 Adverse event	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 Etanercept 10 mg SC twice weekly	1	425	Risk Ratio (M‐H, Fixed, 95% CI)	0.52 [0.27, 1.02]
3.2 Etanercept 25 mg SC twice weekly	2	875	Risk Ratio (M‐H, Fixed, 95% CI)	0.66 [0.45, 0.99]
4 Death	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 Etanercept 10 mg SC twice weekly	1	425	Risk Ratio (M‐H, Fixed, 95% CI)	3.13 [0.13, 76.38]
4.2 Etanercept 25 mg SC twice weekly	2	875	Risk Ratio (M‐H, Fixed, 95% CI)	1.72 [0.23, 12.95]