Table 3.

Associations between baseline factors and treatment switching–stratified by treatment epoch.

Factor at treatment start	Treatment epoch
	1996–2006	2007–2012	2013+
	Adjusted HR (95% CI) p-value	Adjusted HR (95% CI) p-value	Adjusted HR (95% CI) p-value
Age at treatment start (10 year units)	1.05 (1.03, 1.08) <0.001	1.05 (1.04, 1.06) <0.001	1.14 (1.11, 1.16) <0.001
Female sex	1.13 (1.07, 1.20) <0.001	1.11 (1.07, 1.16) <0.001	1.11 (1.06, 1.17) <0.001
EDSS	1.14 (1.13, 1.16) <0.001	1.10 (1.09, 1.11) <0.001	1.02 (1.01, 1.03) 0.001
Calendar year	1.17 (1.16, 1.18) <0.001	1.24 (1.22, 1.25) <0.001	1.08 (1.06, 1.10) <0.001