Table 2.
n = 1049 | Prosigna® molecular subtype | |||||||
---|---|---|---|---|---|---|---|---|
Luminal A | Luminal B | HER2-enriched | Basal-like | |||||
n = 679 | % | n = 350 | % | n = 8 | % | n = 12 | % | |
Age at diagnosis (years) | ||||||||
< 50 | 211 | 31 | 74 | 21 | 3 | 38 | 5 | 42 |
> 50 | 459 | 68 | 271 | 77 | 5 | 63 | 7 | 58 |
Na | 9 | 1 | 5 | 1 | 0 | 0 | 0 | 0 |
Tumor type | ||||||||
Ductal | 522 | 77 | 293 | 83 | 7 | 88 | 11 | 92 |
Lobular | 110 | 16 | 29 | 8 | 0 | 0 | 0 | 0 |
Others | 31 | 5 | 19 | 5 | 0 | 0 | 1 | 8 |
Na | 16 | 2 | 9 | 3 | 1 | 13 | 0 | 0 |
Tumor size (mm) | ||||||||
≤ 20 | 536 | 79 | 234 | 67 | 6 | 75 | 10 | 83 |
> 20 | 143 | 21 | 116 | 33 | 2 | 25 | 2 | 17 |
ER | ||||||||
Positive | 676 | 100 | 350 | 100 | 8 | 100 | 8 | 67 |
Negative | 1 | 0 | 0 | 0 | 0 | 0 | 4 | 33 |
Na | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
PR | ||||||||
Positive | 611 | 90 | 324 | 92 | 5 | 63 | 8 | 67 |
Negative | 66 | 10 | 26 | 7 | 3 | 38 | 4 | 33 |
Na | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ki67 index (%) | ||||||||
< 14 | 399 | 59 | 69 | 20 | 0 | 0 | 0 | 0 |
14–20 | 189 | 28 | 119 | 34 | 1 | 13 | 0 | 0 |
> 20 | 91 | 13 | 162 | 46 | 7 | 88 | 12 | 100 |
Ki67 index (%) | ||||||||
< 13 | 392 | 58 | 64 | 18 | 0 | 0 | 0 | 0 |
> 13 | 287 | 42 | 286 | 81 | 8 | 100 | 12 | 100 |
Histological grade | ||||||||
1 | 81 | 12 | 12 | 3 | 0 | 0 | 0 | 0 |
2 | 379 | 56 | 177 | 50 | 1 | 13 | 2 | 17 |
3 | 25 | 4 | 53 | 15 | 2 | 25 | 6 | 50 |
Na | 194 | 29 | 109 | 31 | 5 | 63 | 4 | 33 |
Prosigna ROR | ||||||||
Low | 461 | 68 | 1 | 0 | 0 | 0 | 1 | 8 |
Intermediate | 194 | 29 | 145 | 41 | 1 | 13 | 9 | 75 |
High | 24 | 4 | 204 | 58 | 7 | 88 | 2 | 17 |
Lymph nodes | ||||||||
0 | 521 | 77 | 286 | 82 | 7 | 88 | 10 | 83 |
1–3 | 158 | 23 | 64 | 18 | 1 | 13 | 2 | 17 |
NA non-available, ER estrogen receptor, PR progesterone receptor, HER human epidermal growth factor receptor 2, ROR risk of recurrence