Table 3.

Concordance between Prosigna^® assay and IHC classifications: Proxy 1, Proxy 2, and Proxy 3 [5–7]

Proxy 1 (n = 1028)	Prosigna®
	LumA	LumB
LumA	391 (38%)	65 (6%)	Kappa	95% CI	Accuracy	TPR	TNR
LumB	287 (28%)	285 (28%)	0.34	(0.288–0.390)	0.66	0.58	0.81

Proxy 2 (n = 990)	Prosigna®
	LumA	LumB
LumA	300 (30%)	45 (5%)	Kappa	95% CI	Accuracy	TPR	TNR
LumB	352 (36%)	293 (30%)	0.27	(0.221–0.315)	0.59	0.46	0.87

Proxy 3 (n = 1020)	Prosigna®
	LumA	LumB
LumA	490 (49%)	117 (11%)	Kappa	95% CI	Accuracy	TPR	TNR
LumB	185 (18%)	228 (22%)	0.37	(0.311–0.427)	0.70	0.73	0.66

IHC immunohistochemistry, CI confidence interval, LumA luminal A, LumB luminal B, TPR true positive rate, TNR true negative rate