Table 4.

Concordance between the Prosigna^® assay and IHC classifications according to the risk of recurrence (ROR): (a) low ROR (0–40) and (b) intermediate (41–60) + high (61–100) ROR

Proxy 1 (n = 407)	Low ROR
	LumA	LumB
LumA	247 (61%)	0 (0%)	Kappa	95% CI	Accuracy	Sensitivity	Specificity
LumB	159 (39%)	1 (0%)	0.008	(-0.007 to 0.022)	0.61	0.61	1.00

Proxy 2 (n = 394)	Low ROR
	LumA	LumB
LumA	186 (47%)	0 (0%)	Kappa	95% CI	Accuracy	Sensitivity	Specificity
LumB	207 (53%)	1 (0%)	0.005	(-0.004 to 0.013)	0.47	0.47	1.00

Proxy 3 (n = 406)	Low ROR
	LumA	LumB
LumA	307 (76%)	1 (0%)	Kappa	95% CI	Accuracy	Sensitivity	Specificity
LumB	98 (24%)	0 (0%)	-0.005	(-0.014 to 0.005)	0.76	0.76	0.00

Proxy 1 (n = 400)	Intermediate + high ROR
	LumA	LumB
LumA	43 (11%)	52 (13%)	Kappa	95% CI	Accuracy	Sensitivity	Specificity
LumB	72 (18%)	233 (58%)	0.202	(0.099 to 0.305)	0.69	0.37	0.82

Proxy 2 (n = 388)	Intermediate + high ROR
	LumA	LumB
LumA	37 (10%)	36 (9%)	Kappa	95% CI	Accuracy	Sensitivity	Specificity
LumB	75 (19%)	240 (62%)	0.223	(0.119 to 0.327)	0.71	0.33	0.87

Proxy 3 (n = 396)	Intermediate + high ROR
	LumA	LumB
LumA	60 (15%)	96 (24%)	Kappa	95% CI	Accuracy	Sensitivity	Specificity
LumB	55 (14%)	185 (47%)	0.163	(0.066 to 0.26)	0.62	0.52	0.66

IHC immunohistochemistry, CI confidence interval, LumA luminal A, LumB luminal B