Fig. 5. Common variant analysis.

a Manhattan plot for trait association test in colony cells. Red line represents the p-value threshold after Bonferroni correction for the number of tested traits and genes (P < 2 × 10⁻¹⁰) Blue line represents the p-value threshold for hits with suggestive evidence (P < 4.1 × 10⁻⁸). b Impact of knockdown of NF1 and SUZ12 in U2OS cells on Cytoplasm_RadialDistrubtion_RadialCV_ER_3of4 (P = 0.04 NF1, P = 0.005 SUZ12, Welch’s two-sided T test). Data are presented in a Tukey-style boxplot with the median (Q2) and the first and the second quartiles (Q2, Q3) and error bars defined by the last data point within ±1.5-times the interquartile range (n = 8 control biological replicate, 4 biological replicates for each target gene).