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. 2024 Jan 6;8:6. doi: 10.1038/s41698-023-00493-7

Fig. 8. Analysis of TCGA melanoma and GTEx healthy individual databases for expression of NUMB isoforms and overall survival (OS) of melanoma patients.

Fig. 8

a Transcript level expression of four NUMB isoforms in melanoma patients compared to healthy individuals. b The OS was compared between melanoma patients with “high PLK1 and low NUMB-isoforms” (red, levels > median) and “low PLK1 and high NUMB-isoforms” (cyan, levels < median). c The OS was compared between melanoma patients with “high NOTCH1 and low NUMB” (red, levels > median) and “low NOTCH1 and high NUMB” (cyan, levels < median); “high PLK1 and high N-cadherin” (red, levels > median) and “low PLK1 and low N-cadherin” (cyan, levels < median); “high PLK1 and low E-cadherin” (red, levels > median) and “low PLK1 and high E-cadherin” (cyan, levels < median). d The OS was compared for combined high/low expression of triple genes PLK1, NUMB, and NOTCH; PLK1-NUMB-N-cadherin; and PLK1-NUMB-E-cadherin between melanoma patients. For OS analysis (n = 479 patients with melanoma from TCGA melanoma database), Kaplan-Meier curves were plotted using the R package “survminor” (v0.4.6). OS Overall survival.