Fig. 7. Locomotor deficits elicited by secreted αSyn.

a and b Mice (n = 6) of each group were assayed by an accelerating rod that started at 4 RPM and reached 14 RPM (a) or 45 RPM (b) in 300 s. Data is shown as the latency to fall (calculated as the averaged time in seconds to fall)±SD. *p < 0.05 (one-way ANOVA followed by the post hoc Dunnett’s test). c, d Representative heat maps of residence time (c) and trajectory plots (d) derived from the open field test within a 20 min session divided into four consecutive sessions (bins) of 5 min each. Two representative maps from mice transduced with eGFP (n = 6), sp2-αSyn (n = 6), or wt-αSyn (n = 5) AAVs for 4 months are shown.