Figure 2.

High is defined as 75–100 percentile CTLA-4 RNA expression rank; low–moderate is defined as 0–74. Percentages in the bar graph are of patients with that designated level of CTLA-4 RNA expression. Transcript abundance was normalized to an internal housekeeping gene profile dataset and ranked (0–100 percentile rank) in a standardized manner to a reference dataset of 735 tumors spanning 35 tumor histologies. Tumor types with ⩾ 10 samples were included. In addition, melanoma and cervical cancer were included because anti-CTLA-4 treatment is approved for melanoma and in the case of cervical cancer, CTLA-4 expression was high.