Table 1.
Demographics
| A−T− (n = 19) | A+T− (n = 28) | A+T+ (n = 21) | p | |
|---|---|---|---|---|
| Sex: F/M | 14/5 | 13/15 | 14/7 | 0.13 |
| Age, years | 72.7 (7.5) | 74.3 (8.5) | 76.2 (6.0) | 0.35 |
| Education, years | 15.9 (2.2) | 16.6 (2.6) | 16.9 (2.4) | 0.42 |
| CDR | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.35 |
| MMSE | 29 (28, 30) | 29 (29, 30) | 29 (27, 30) | 0.34 |
| WMH volumes, cm3 | 1.7 (0.5, 4.1) | 2.0 (0.7, 9.6) | 1.8 (0.6, 10.3) | 0.65 |
| Global amyloid-PET SUVR | 1.02 (0.99, 1.04) | 1.17 (1.14, 1.30) | 1.35 (1.19, 1.47) | <0.001a,b |
| Tau-PET SUVR | 1.16 (1.11, 1.19) | 1.16 (1.12, 1.20) | 1.27 (1.25, 1.34) | <0.001b,c |
| Hippocampal volume, cm3 | 8.0 (0.8) | 8.0 (0.9) | 7.9 (0.8) | 0.88 |
Values are expressed as mean with standard deviation for normally distributed data, otherwise expressed as median with interquartile range.
a
Statistically significant difference between A−T− and A+T− (p < 0.001).
b
Statistically significant difference between A−T− and A+T+ (p < 0.001).
c
Statistically significant difference between A+T− and A+T+ (p < 0.001).
A, amyloid; CDR, clinical dementia rating; MMSE, mini-mental state examination; PET, positron emission tomography; SUVR, standardized uptake value ratio; T, tau; WMH, white matter hyperintensity.