Table 2.
Top phenome-wide signals in main analysis and their respective effect sizes across conditions.
| Phenotype | ORa | 95% CI lowera | 95% CI uppera | P | N Cases | N Controls |
|---|---|---|---|---|---|---|
| All adjusted for smoking status b | ||||||
| Cancer of bronchus (lung) | 1.114 | 1.073 | 1.157 | 1.78E−08 | 2926 | 391 072 |
| Emphysema | 1.127 | 1.079 | 1.176 | 5.56E−08 | 2236 | 356 292 |
| Cancer within the respiratory system | 1.100 | 1.062 | 1.139 | 8.55E−08 | 3397 | 391 072 |
| Obstructive chronic bronchitis | 1.055 | 1.034 | 1.076 | 1.70E−07 | 10 649 | 356 292 |
| Chronic bronchitis | 1.052 | 1.032 | 1.074 | 4.24E−07 | 10 856 | 356 292 |
| Chronic airway obstruction | 1.046 | 1.028 | 1.065 | 8.40E−07 | 13 261 | 356 292 |
| All unadjusted for smoking | ||||||
| Cancer of bronchus (lung) | 1.099 | 1.059 | 5.633 | 6.79E−07 | 2945 | 392 431 |
| Emphysema | 1.108 | 1.062 | 10.633 | 2.56E−06 | 2252 | 357 462 |
| Cancer within the respiratory system | 1.087 | 1.050 | 6.633 | 2.31E−06 | 3419 | 392 431 |
| Obstructive chronic bronchitis | 1.039 | 1.019 | 7.633 | 1.39E−04 | 10 747 | 357 462 |
| Chronic bronchitis | 1.036 | 1.017 | 8.633 | 2.92E−04 | 10 956 | 357 462 |
| Chronic airway obstruction | 1.032 | 1.014 | 9.633 | 4.19E−04 | 13 372 | 357 462 |
| Current smokers | ||||||
| Cancer of bronchus (lung) | 1.222 | 1.144 | 1.306 | 2.97E−09 | 1007 | 38 856 |
| Emphysema | 1.170 | 1.090 | 1.257 | 1.40E−05 | 847 | 33 802 |
| Cancer within the respiratory system | 1.206 | 1.131 | 1.285 | 9.53E−09 | 1081 | 38 856 |
| Obstructive chronic bronchitis | 1.098 | 1.060 | 1.137 | 1.65E−07 | 3802 | 33 802 |
| Chronic bronchitis | 1.095 | 1.058 | 1.134 | 2.90E−07 | 3846 | 33 802 |
| Chronic airway obstruction | 1.089 | 1.053 | 1.126 | 5.71E−07 | 4179 | 33 802 |
| Former smokers | ||||||
| Cancer of bronchus (lung) | 1.072 | 1.016 | 1.130 | 1.12E−02 | 1423 | 137 624 |
| Emphysema | 1.090 | 1.027 | 1.156 | 4.44E−03 | 1161 | 123 841 |
| Cancer within the respiratory system | 1.066 | 1.015 | 1.120 | 1.11E−02 | 1654 | 137 624 |
| Obstructive chronic bronchitis | 1.051 | 1.022 | 1.081 | 5.57E−04 | 5195 | 123 841 |
| Chronic bronchitis | 1.050 | 1.021 | 1.080 | 6.16E−04 | 5270 | 123 841 |
| Chronic airway obstruction | 1.044 | 1.017 | 1.071 | 1.16E−03 | 6312 | 123 841 |
| Ever smokers c | ||||||
| Cancer of bronchus (lung) | 1.109 | 1.065 | 1.156 | 8.55E−07 | 2430 | 176 468 |
| Emphysema | 1.100 | 1.051 | 1.150 | 3.86E−05 | 2008 | 157 632 |
| Cancer within the respiratory system | 1.099 | 1.057 | 1.143 | 1.92E−06 | 2735 | 176 468 |
| Obstructive chronic bronchitis | 1.048 | 1.026 | 1.071 | 2.14E−05 | 8997 | 157 632 |
| Chronic bronchitis | 1.047 | 1.024 | 1.069 | 3.28E−05 | 9116 | 157 632 |
| Chronic airway obstruction | 1.042 | 1.021 | 1.063 | 7.11E−05 | 10 491 | 157 632 |
| Never smokers | ||||||
| Cancer of bronchus (lung) | 1.043 | 0.954 | 1.141 | 3.53E−01 | 496 | 214 592 |
| Emphysema | 1.154 | 1.008 | 1.322 | 3.83E−02 | 228 | 198 649 |
| Cancer within the respiratory system | 1.032 | 0.955 | 1.114 | 4.28E−01 | 662 | 214 592 |
| Obstructive chronic bronchitis | 0.983 | 0.937 | 1.032 | 4.89E−01 | 1652 | 198 649 |
| Chronic bronchitis | 0.980 | 0.935 | 1.027 | 3.95E−01 | 1740 | 198 649 |
| Chronic airway obstruction | 0.996 | 0.960 | 1.035 | 8.49E−01 | 2770 | 198 649 |
OR, Odds ratio from the logistic regression estimates of the wGRS effects on each phenotype; CI, Confidence interval; P, significance value of the wGRS estimate; N, sample Number as cases and controls. Italicized text indicates different groups. All analyses are adjusted for age at recruitment, genetic sex, and first ten genetic principal components.
aThe OR was calculated as the exponent of the regression beta, the 95% CI lower was calculated as: exp(beta − 1.96*SE); while the 95% CI upper was calculated as: exp(beta + 1.96*SE). The ORs and CIs were then transformed by exponentiating them to the power of 1 SD of the wGRS.
bN = 1435 excluded for ‘prefer not say’ in smoking status.
cEver smokers defined by combining current and former smokers’ groups.