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. 2023 Sep 14;32(1):61–68. doi: 10.1038/s41431-023-01454-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The prospective cohort was ascertained via the top pathway, the retrospective cohort via the bottom pathway. Individuals who originally accepted the in person offer to register to CTRL but did not sign up were sent an e-mail invitation at the completion of the recruitment period, and those registrations were included in the retrospective cohort (represented by dashed line). The rest of the retrospectively invited group is 353 individuals who were recruited into the Flagship but were never offered CTRL. The percentages of the prospective and retrospective registered groups were calculated based on the individuals who were invited to participate to CTRL. Other percentages are based on the previous step in the figure.