Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 7;14:742. doi: 10.1038/s41598-023-50262-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The high-affinity interaction between lirilumab and KIR2DL3 is affected by polymorphisms present in KIR2DL3 variants and in KIR2DS4. Biolayer interferometry kinetics plots are shown for lirilumab (IgG1) and three KIR2DL3 mutants in neutral pH conditions. In each assay, IgG1 lirilumab was loaded onto AHC sensor tips and equilibrated to assay buffer prior to analyte binding. Each data series consists of 6 two-fold dilutions starting at an analyte concentration of 250 nM (except KIR2DL3 D47N, where the peak concentration is 500 nM). Representative plots from among three assay replicates are shown.